Quantum group theorists have studied the idea that space-time coordinates are non-commutative and tried to construct quantum field theories with non-commutative space-time coordinates (see this). My impression is that this approach has not been very successful. In Minkowski space one introduces antisymmetry tensor Jkl and uncertainty relation in linear M4 coordinates mk would look something like [mk, ml] = lP2Jkl, where lP is Planck length. This would be a direct generalization of non-commutativity for momenta and coordinates expressed in terms of symplectic form Jkl.
1+1-D case serves as a simple example. The non-commutativity of p and q forces to use either p or q. Non-commutativity condition reads as [p,q]= hbar Jpq and is quantum counterpart for classical Poisson bracket. Non-commutativity forces the restriction of the wave function to be a function of p or of q but not both. More geometrically: one selects Lagrangian sub-manifold to which the projection of Jpq vanishes: coordinates become commutative in this sub-manifold. This condition can be formulated purely classically: wave function is defined in Lagrangian sub-manifolds to which the projection of J vanishes. Lagrangian manifolds are however not unique and this leads to problems in this kind of quantization. In TGD framework the notion of "World of Classical Worlds" (WCW) allows to circumvent this kind of problems and one can say that quantum theory is purely classical field theory for WCW spinor fields. "Quantization without quantization would have Wheeler stated it.
GCI poses however a problem if one wants to generalize quantum group approach from M4 to general space-time: linear M4 coordinates assignable to Lie-algebra of translations as isometries do not generalize. In TGD space-time is surface in imbedding space H=M4× CP2: this changes the situation since one can use 4 imbedding space coordinates (preferred by isometries of H) also as space-time coordinates. The analog of symplectic structure J for M4 makes sense and number theoretic vision involving octonions and quaternions leads to its introduction. Note that CP2 has naturally symplectic form.
Could it be that the coordinates for space-time surface are in some sense analogous to symplectic coordinates (p1,p2,q1,q2) so that one must use either (p1,p2) or (q1,q2) providing coordinates for a Lagrangian sub-manifold. This would mean selecting a Lagrangian sub-manifold of space-time surface? Could one require that the sum Jμν(M4)+ Jμν(CP2) for the projections of symplectic forms vanishes and forces in the generic case localization to string world sheets and partonic 2-surfaces. In special case also higher-D surfaces - even 4-D surfaces as products of Lagrangian 2-manifolds for M4 and CP2 are possible: they would correspond to homologically trivial cosmic strings X2× Y2⊂ M4× CP2, which are not anymore vacuum extremals but minimal surfaces if the action contains besides Käction also volume term.
But why this kind of restriction? In TGD one has strong form of holography (SH): 2-D string world sheets and partonic 2-surfaces code for data determining classical and quantum evolution. Could this projection of M4 × CP2 symplectic structure to space-time surface allow an elegant mathematical realization of SH and bring in the Planck length lP defining the radius of twistor sphere associated with the twistor space of M4 in twistor lift of TGD? Note that this can be done without introducing imbedding space coordinates as operators so that one avoids the problems with general coordinate invariance. Note also that the non-uniqueness would not be a problem as in quantization since it would correspond to the dynamics of 2-D surfaces.
The analog of brane hierarchy for the localization of spinors - space-time surfaces; string world sheets and partonic 2-surfaces; boundaries of string world sheets - is suggesetive. Could this hierarchy correspond to a hierarchy of Lagrangian sub-manifolds of space-time in the sense that J(M4)+J(CP2)=0 is true at them? Boundaries of string world sheets would be trivially Lagrangian manifolds. String world sheets allowing spinor modes should have J(M4)+J(CP2)=0 at them. The vanishing of induced W boson fields is needed to guarantee well-defined em charge at string world sheets and that also this condition allow also 4-D solutions besides 2-D generic solutions. This condition is physically obvious but mathematically not well-understood: could the condition J(M4)+J(CP2)=0 force the vanishing of induced W boson fields? Lagrangian cosmic string type minimal surfaces X2× Y2 would allow 4-D spinor modes. If the light-like 3-surface defining boundary between Minkowskian and Euclidian space-time regions is Lagrangian surface, the total induced Kähler form Chern-Simons term would vanish. The 4-D canonical momentum currents would however have non-vanishing normal component at these surfaces. I have considered the possibility that TGD counterparts of space-time super-symmetries could be interpreted as addition of higher-D right-handed neutrino modes to the 1-fermion states assigned with the boundaries of string world sheets.
An alternative - but of course not necessarily equivalent - attempt to formulate this picture would be in terms of number theoretic vision. Space-time surfaces would be associative or co-associative depending on whether tangent space or normal space in imbedding space is associative - that is quaternionic. These two conditions would reduce space-time dynamics to associativity and commutativity conditions. String world sheets and partonic 2-surfaces would correspond to maximal commutative or co-commutative sub-manifolds of imbedding space. Commutativity (co-commutativity) would mean that tangent space (normal space as a sub-manifold of space-time surface) has complex tangent space at each point and that these tangent spaces integrate to 2-surface. SH would mean that data at these 2-surfaces would be enough to construct quantum states. String world sheet boundaries would in turn correspond to real curves of the complex 2-surfaces intersecting partonic 2-surfaces at points so that the hierarchy of classical number fields would have nice realization at the level of the classical dynamics of quantum TGD.
For background see the chapter How the hierarchy of Planck constants might relate to the almost vacuum degeneracy for twistor lift of TGD?.
For a summary of earlier postings see Latest progress in TGD.