## Monday, November 21, 2005

### Could Genetic Code Be Understood Number Theoretically?

The discussions with Sampo Vesterinen about topics only remotely related to genetic code led by a pure accident to an observation which stimulated feverish two week's period of work with a number theoretical model of genetic code. The number of DNA triplets is 64. This inspires the idea that DNA sequence could be interpreted as an expansion of an integer using 64 as the base. Hence given DNA triplet would represent some integer in n=1,...,6 (sequences of I Ching symbols give a beautiful representation of numbers in 64 base)). The discussions stimulated an observation putting bells ringing. The number of primes smaller than 64 is 18. Together with 0, and 1 this makes 20: the number of aminoacids!

1. Questions

The finding just described stimulates a whole series of questions.

Do aminoacids correspond to integers in the set consisting of primes ≤ 61 and {0,1}. Does aminoacid sequence have an interpretation as a representation as a sequence of integers consisting of 0, 1 and products of primes p=2,...,61? Does the aminoacid representing 0 have an interpretation as kind of period separating from each other structural units analogous to genes representing integers in the sequence so that we would quite literally consists of sequences of integers? Do 0 and 1 have some special biological properties, say the property of being biologically inert both at the level of DNA and aminoacids?

Does genetic code mediate a map from integers 0,...,63 to set S such that 0 and 1 are mapped to 0 and 1? If so then three integers 2≤= n &le 63 must correspond to stopping sign codons rather than primes. What stopping sign codon property means at the level of integers? How the map from integers 2,...,61 to the primes p=2,...,61 is determined?

2. The chain of arguments leading to a number theoretical model for the genetic code

The following chain of arguments induced to large part by concrete numerical experimentation leads to a model providing a partial answer to many of these questions.

1. The partitions of any positive integer n can be interpreted in terms of number theoretical many boson states. The partitions for which a given integer appears at most once have interpretation in terms of fermion states. These states could be identified as bosonic and fermionic states of Super Virasoro representation with given conformal weight n.

2. The generalization of Shannon entropy by replacing logarithms of probabilities with the logarithms of p-adic norms of probabilities allows to have systems with negative entropy and thus positive negentropy. The natural requirement is that n corresponds to such prime p≤ 61 that the negentropy assigned to n is maximal in some number theoretic thermodynamics. The resulting correspondence n → p(n) would naturally determine the genetic code.

3. One can assign to the bosonic and fermionic partitions a number theoretic thermodynamics defined by a Hamiltonian. Purely bosonic and fermionic thermodynamics are defined by corresponding partition functions ZB and ZF whereas supersymmetric option is defined by the product ZB\times ZF. Supersymmetric option turns out to be the most realistic one.

4. The simplest option is that Hamiltonian depends only on the number r of the integers in the partition. The dynamics would be in a well defined sense local and would not depend on the sizes of summands at all. The thermodynamical states would be degenerate with degeneracy factors given by total numbers dI(n,r) of partitions of type I=B,F. The invariants known as rank and crank define alternative candidates for basic building blocks of Hamiltonian.

5. Ordinary exponential thermodynamics based on, say eH/T= q0^{r-1}, q0 a rational number, produces typically unrealistic genetic codes for which most integers are mapped to small primes p≤ 11 and many primes are not coded at all. The idea that realistic code could result at some critical temperature fails also.

6. Quantum criticality and fractality of TGD Universe inspire the idea that the criticality is an inherent property of Hamiltonian rather than only thermodynamical state. Hence Hamiltonian can depend only weakly on the character of the partition so that all partitions contribute with almost equal weights to the partition function. Fractality is achieved if Boltzmann factors are given by e-H/T=(r+r0)n0 so that H(r)=log(r+r0) serves as Hamiltonian and n0 corresponds to the inverse temperature. The super-symmetric variant of this Hamiltonian yields the most realistic candidates for the genetic code and there are good hopes that a number theoretically small perturbation not changing the divisors p≤ 61 of partition function but affecting the probabilities could give correct degeneracies.

7. Numerical experimentation suggests however that this might not be the case and that simple analytic form of Hamiltonian is too much to hope for. A simple argument however shows that e-H/T=f(r) could be in quantum critical case be deduced from the genetic code by fixing the 62 values of f(r) so that the desired 62 correspondences n→ p(n) result. The idea about almost universality of the genetic code would be replaced with the idea that quantum criticality allows to engineer a genetic code maximizing the total information associated with DNA triplets.

For the details of the number theoretic model of genetic code see the new chapter Could Genetic Code Be Understood Number Theoretically?.