Could this picture be applied in a reverse direction at the level of basic biology?
- Axon conducts in a preferred direction: in this sense the axon behaves like a semiconductor. This suggests that semiconductor analogy applies to neurons and axons and nerve pulse conduction. The transistor picture is however too simple as such. The incoming nerve pulses act as bits and determine whether the neuron fires by generating a bit as a nerve pulse. The charge for the counterpart of base would be affected by the incoming nerve pulses so that a single neuron would act as a gate, whose output as nerve impulse is determined by the incoming nerve pulses as bits.
- Nerve pulse would correspond to the change for the direction of a bit conducted along the axon. This suggests that the axon and cell membrane can be regarded as collections of transistor-like systems defined by basic units, which have size scales of order 10-8 meters, which is the size scale of ion channels. In the ground state, the state of all these transistors correspond to the same value of bit (note the analogy with fermionic ground state in the original Dirac model of fermion). Nerve pulse means a temporary change of the direction of the bit conducted along the axon.
- This picture is supported by the model of the neuronal membrane as Josephson junction (see this) in which the ground state of the axon corresponds to a propagating soliton sequence with each soliton representing a single bit, say b=1. Soliton sequence fixes the values of axonal bits to say b=1. Nerve pulse means propagation of a perturbation in which the membrane potential has changed sign and corresponds to an opposite bit value. This is natural: only deviations from the equilibrium configuration carry relevant information.
- The resting potential is negative, which means that the cell interior (exterior) is negatively (positively) charged. If the Pollack effect occurs in the neuronal exterior, membrane potential is reduced in magnitude. The same occurs if the reverse Pollack effect takes place in the neuronal interior.
This would suggest that the Pollack effect in the neuronal exterior and its reversal in the neuronal interior can temporarily change the sign of the membrane potential representing a bit and generate a nerve pulse. Since the stable ground states of neuronal and axonal membranes correspond to say b=1, the nerve pulse must have a finite duration. Physically the stability of the membrane potential would correspond to the fact that the generation of dark nuclear binding energy (much smaller than the ordinary binding energy) in the formation of dark nuclei from dark protons at the MB makes b=1 energetically favored.
- The Pollack effect would correspond to the transition -OH \rightarrow O- + dark proton at the monopole flux tube. The energy difference Δ E between these two states must be small enough and would be in the range 01-.05 eV (see this). Its sign determines whether the Pollack effect occurs spontaneously. The first guess is that either the resting potential or a voltage associated with either lipid layer serves in the role of the base potential in turn controlling the value of Δ E.
For small enough values of Δ E, the Pollack effect can take place. It is expected to be more probable at the positively charged exterior side of the membrane. When Δ E too large, the dark nuclei become energetically unstable and this induces reverse Pollack effect in the interior of the membrane reducing the membrane potential. The transfer of positive protonic charge from the exterior to the interior would be the net effect, reducing the magnitude of the membrane potential and even changing its sign.
Since the soliton sequence defines the stable value of the membrane potential, the duration of the nerve pulse must be finite. The stability of dark nuclei at the magnetic body would be the energetic reason for this.
- Interestingly, the search of axon-like materials suitable for a more efficient computation is under away (see for instance this).
- Andrew Adamatsky (see this), who has studied sponges and found that they show electrical activity sequences consisting of analogs of action potentials ('spikes') (see this). The spikes have the same amplitude scale as miniature potentials appearing in neural systems. The semiconductor analogy, based on a cell membrane as Josephson junction with soliton sequence as a ground state and Pollack effect, is suggestive as a model for the generation of spikes.
- The chirality of the DNA strand gives it a directionality analogous to the semiconductor type behavior. The bases of DNA base pairs A-T and C-G are connected by hydrogen bonds (see this), which suggests the possibility of Pollack effect suggested to be catalyzed by the presence of hydrogen bonds.
DNA transcription and translation are preceded by the splitting of the DNA double strand to separate strands is a process analogous to the opening of a zipper. Could the opening be induced by the analog of nerve pulse conduction along the double strand? Could also the DNA double strand be regarded as a Josepson junction, with ground state modellable as a Sine-Gordon soliton sequence? Could also now the Pollack effect and its reversal change the sign of the voltage between the members of the base pair temporarily and induce the analog of nerve pulse conduction?
For a summary of earlier postings see Latest progress in TGD.
For the lists of articles (most of them published in journals founded by Huping Hu) and books about TGD see this.